A Revolutionary Innovation in Automated Nucleic Acid Extraction

Filter Negative-Pressure
Universal Automatic
Nucleic Acid Extractor TT-A-8

A revolutionary automated nucleic acid extraction platform independently developed by ZD Biotech. Utilizing nano-scale porous solid-phase nucleic acid adsorption material and negative-pressure operation to eliminate cross-contamination, with universal compatibility across all sample types and 10x sensitivity improvement.

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Filter Negative-Pressure Universal Automatic Nucleic Acid Extractor

Industry Pain Points

Limitations of Existing Technology

Current magnetic bead-based automated nucleic acid extraction devices have significant shortcomings

Non-Universal Platform

Most devices can only process a single sample type, such as blood only. Clinical settings require processing diverse specimens including stool, sputum, and tissue — a single-purpose platform cannot meet these demands.

Sample Cross-Contamination

Magnetic bead-based extraction systems are prone to sample-to-sample cross-contamination during processing, leading to false-positive results that severely compromise clinical diagnostic accuracy.

Inadequate Sensitivity

Domestic COVID-19 nucleic acid testing sensitivity is only 200 copies/mL, frequently producing false-negative results with high missed-detection risk. Poor extraction performance limits the clinical utility of molecular testing.

Product Advantages

Six Core Technical Features

Breakthrough innovations in filter negative-pressure universal nucleic acid extraction technology

🧬

Universal Compatibility

The only automated nucleic acid extractor suitable for all sample types, including blood, sputum, tissue, stool, swabs, and more.

📦

Superior Reagent Stability

Extended shelf life with stable, reliable reagent formulations that reduce replacement frequency and operating costs.

🎯

High Purity Extraction

Excellent reproducibility with minimal batch-to-batch variation, ensuring reliability and consistency in downstream molecular testing.

⚡

Rapid Automation

Fully automated operation with fast extraction speed, completing the entire nucleic acid extraction workflow in < 30 minutes.

🛡️

Negative-Pressure Anti-Contamination

Negative-pressure operation fundamentally eliminates sample-to-sample cross-contamination, removing false-positive risks at the source.

📈

10x Sensitivity Improvement

Large sample processing capacity significantly enhances detection sensitivity, reducing false-negative rates for more precise molecular diagnostics.

Core Technology

Nano-Scale Porous Solid-Phase Nucleic Acid Adsorption Material

The core technology lies in the independently developed novel nucleic acid adsorption material

Breakthrough Nucleic Acid Adsorption Material

Our independently developed nano-scale porous solid-phase nucleic acid adsorption material features strong nucleic acid binding capacity, excellent permeability, and stable chemical properties.

This novel material matches the excellent nucleic acid adsorption capability of widely used adsorption membranes, yet overcomes the critical drawbacks of conventional membranes — poor permeability and deformation under pressure.

By perfectly combining nucleic acid adsorption efficiency with physical stability, this material forms the core foundation of filter negative-pressure extraction technology, fundamentally solving the industry-wide challenge of silica membrane deformation and clogging under negative pressure.

Nano-scale porous solid-phase nucleic acid adsorption material

Technical Principle

Filter Negative-Pressure Extraction Workflow

Complete nucleic acid adsorption-washing-elution workflow based on nano-scale porous filter technology

Filter negative-pressure nucleic acid extraction principle diagram

Sample Solution Containing Nucleic Acid

The processed sample solution is added to the extraction tube. Nucleic acids are driven through the porous filter under negative pressure.

Nucleic Acid Adsorption

The sample solution is drawn away from port F, and nucleic acids are specifically adsorbed onto filter G.

B·C·D

Washing & Impurity Removal

Wash buffers from B, C, and D are sequentially drawn through port F, cleaning proteins and other impurities from the filter.

T·E

Elution & Collection

In tube T, piston E is pumped up and down to elute the purified nucleic acid from filter G into the elution buffer.

Specifications

Performance Metrics

⏱️

<30min

Extraction Time

📦

Universal

Sample Types

📈

10×

Sensitivity Gain

🛡️

Cross-Contamination

⚗️

Nano-Porous

Material Technology

💰

Low

Reagent Cost

Filter Negative-PressureUniversal AutomaticNucleic Acid Extractor TT-A-8